The aim of the project is to examine the capability of the sensor VD6281 to evaluate the Peripheral Oxygen Saturation and the Heart Rate, in real-time and non-invasively. Nowadays, the SpO2 evaluations are mostly employed by transmission pulse oximeter, photoplethysmography application that works with the red and the IR LEDs. Each LEDs emit a light beam that it passes through the irradiated tissues, interacts with these and is partly absorbed. The residual transmitted rays are collected by a photodiode, opposite to the light beams direction. In this way, the PPG signal is obtain and it allows to estimate the Peripheral Oxygen Saturation.