DNA nanotechnology is a promising technique for DNA and protein sensors, owing to its affinity to biological molecules and to the possibility of precisely tuning geometry and functions to optimize the actuation and signal transduction. Specifically, one can design two- and three-dimensional nanometric shapes with DNA origami, where a long DNA strand is folded by hybridization of shorter DNA strands. While a large variety of biosensing techniques exists, the versatility and programmability of DNA nanotechnology could make it a valid competitor in this field, overcoming some of the previous limitations. This project aims to demonstrate a DNA strand sensor that exploits DNA origami as the bioreceptor and redox indicators as transducers.