Nowadays the application of nanotechnology in the field of biomedicine is rapidly rising and nanotechnology-based chemotherapy is widely apply to treat many type of cancers, such as hematological malignancies. This family of cancers includes various malignant neoplasms that affect blood or lymph systems. The interest of our study is focused on the drugs used to treat leukemia, which is an acute or chronic disease characterized by an abnormal increase in the number of white blood cells in the tissues and often also in the blood. To treat leukemia, many type of treatments are suggested and the most used technique is chemotherapy.