Cardiovascular diseases (CVDs) are the main cause of death worldwide. Autologous vessels, such as the saphenous vein, are nowadays the gold standard grafts for the surgical treatment of CVDs for small-diameter vessels. However, the procedure doesn’t go without drawbacks, like their limited availability and the incidence of post-operative complications. Alternative vessels sources have been taken into consideration leading to the investigation of tissue-engineered vascular grafts (TEVGs). Currently, polymers like Dacron and ePTFE are used to fabricate vessels substitutes that are successfully applied for large diameter vessels (d > 7 mm) replacement. When it comes to small diameter grafts (d < 5 mm), however, the failure rate of these synthetic grafts becomes significantly higher.