This Master’s Thesis presents the development of a biosensing platform that leverages the memristive properties of silicon nanowires for detecting Prostate-Specific Antigen (PSA), a critical biomarker for early-stage prostate cancer diagnosis. The platform integrates three key components: silicon nanowires with nickel silicide (NiSi) pads as the core biosensors, gold electrodes for electrical measurements, and a PDMS-based microfluidic platform, which guides the sample to the active sensing area, optimizing reagent usage, and ensuring the necessary humidity conditions for biological reactions. The core of the biosensing device consists of two-terminal, vertically stacked Schottky barrier silicon nanowire structures, fabricated through electron beam lithography and Bosch etching processes.