In tissue engineering (TE), biochemical and physical stimuli have been shown to be essential for supporting various biological processes, such as promoting cell differentiation and tissue maturation. Conventional 2D cultures using Petri dishes or flasks are static systems that do not adequately mimic the three-dimensional environment of native tissue. They fail to ensure the even distribution of oxygen and nutrients and do not provide the necessary physical stimuli. Bioreactors are culture devices designed to provide defined biochemical and physical stimuli to promote in vitro the development of biological processes under closely monitored and controlled conditions. They are therefore fundamentally important to overcome the limitations of static cell cultures and ensure process standardization.