Stroke is the second leading cause of death in Europe and often results in severe impairment. For individuals with Spinal Cord Injury (SCI), therapeutic techniques help in restoring lost motor functions, preventing muscle atrophy, improving blood circulation, managing pain, and enhancing autonomy. The rehabilitative treatment of the Functional Electrical Stimulation (FES) uses electrical pulses to stimulate muscles at the level of the neuromuscular junctions to recover their physiological activity. Since the efficacy of FES relies on the low-energy pulses injected into the patient, it is essential to monitor the patient’s muscle activity during the FES to regulate stimulation energy. An open challenge in research seeks to automate the adjustment of stimulation patterns based on the subject’s response within a closed-loop system.