Multiple Sclerosis (MS) is a progressive disease of the central nervous system. Among its symptoms, motor and cognitive impairments (from upper limb tremor to attention deficit) can severely affect the individual capability to perform activities of daily living. Consequently, motor and cognitive rehabilitation procedures constitute a priority for people with MS, and their beneficial effects have been proven. However, the effectiveness of the repetitive exercises adopted in rehabilitation typically depends on factors like the motivation of the patients, leading to difficulties in clinical compliance. Thus, engaging people with MS in performing the expected tasks is a challenge that must be faced for improving the individual adherence to the clinical procedures.