Recent advancements in wearable technology have led to a significant improvement in personalized health monitoring. Researchers in biosensing are developing innovative devices and techniques for analyzing biomolecules, such as lactate, glucose, uric acid, DNA, and antibodies, to diagnose and monitor diseases and biological processes. A promising area of research is Raman scattering-based optical biosensing, a non-destructive, label-free analytical technique that identifies chemical compounds through the inelastic scattering of light. This method has been widely utilized in several fields, such as biology, chemistry, and medicine. The potential of Raman spectroscopy in detecting chemical compounds and properties of biomolecules is driving the development of new biosensor platforms based on the Raman effect.