Since the first Wright Brothers flight, there has been a continuous development of new kinds of vehicles to make airplane transportation safer, faster, and cheaper. The last of these innovative projects is Stratofly, financed by the European Union, a new type of civil aircraft two-stage to orbit. Stratoflay, in the next future, is going to carry passengers from Bruxelles to Sydney in just a few hours. It will be possible thanks to the high cruise altitude in the outer atmosphere and the Mach 8 speed reached. From this kind of concept, it is possible to evolve new varieties of vehicles TSTO with many different mission profiles.