The purpose of this thesis work is to develop a methodology that allows to model a Turbulent Jet Ignition Predictive Combustion through the usage of the latest version of the software GT-ISE (v2020). The work is developed in collaboration with Maserati S.p.A. (located in Modena - MO) and Powertech Engineering S.r.l. (Torino - TO). Turbulent Jet Ignition (TJI) is an advanced pre-chamber initiated combustion system for an otherwise standard spark ignition engine found in current on-road vehicles. Turbulent Jet Ignition combustion systems produce multiple and distributed ignition sites, enabling very fast burn rates and allowing for increased levels of dilution when compared to conventional spark ignition combustion.