Digital Twin and HMI for collaborative autonomous mobile robots in flexible logistics. The digital transformation is pervading our society, boosted by the development of new technologies and a lot of companies are undergoing radical changes, which apply both to products and processes, in order to comply with the requirements that the competition imposes. This thesis work has been drawn up during a collaboration for a project, whose specialization area is the smart factory, with Reply S.p.A. The title of this project is ICOSAF (Integrated COllaborative Systems for smArt Factory) and its leader is CRF (Centro Ricerche Fiat). In particular, its aim is to develop and integrate technologies for collaborative workspaces following the principles of industry 4.0 (interconnected automation) and industry 5.0, which is about humanization and re-use of resources.