Industrial Control Systems (ICS) are undergoing a deep transformation of their communication infrastructures towards increased connectivity of devices and extreme flexibility of industrial plants. This is seen within the Industry 4.0 and Factory of the Future (FoF) frameworks. Innovative industrial applications exploit benefits from Software Defined Network (SDN) and Network Function Virtualization (NFV) approaches; they can bring several advantages, such as a detachment from the traditional Industrial Network design and the power to administer the entire network environment from a centralized point. As the higher flexibility of these systems will require frequent network reconfigurations, an enhanced level of automation in the management of cybersecurity will be necessary.