Parkinson's disease is a chronic neurodegenerative disorder, second in frequency only to Alzheimer's disease. Although the well-acknowledged motor symptoms dominated the clinical scenario for a long time, people with a diagnosis of Parkinson's disease typically disclose several life-debilitating non-motor symptoms, even at the early stages of the disorder. Furthermore, typical antiparkinsonian medications such as levodopa also proved to affect the non-motor manifestations, inducing them to fluctuate during the day. The non-motor signs include autonomic symptoms that are addressed to neuronal damages in the autonomic nervous system. Among them, cardiovascular dysautonomia, caused by the loss of sympathetic and parasympathetic innervation throughout the heart, has been reported to precede the motor stage and to progress in parallel with the disease.